Experimental Drug Slows Decline among Alzheimer's Patients
2022-09-29
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1Drugmakers Biogen and Eisai say their experimental drug lecanemab slowed the progress of Alzheimer's disease in a large human study the companies did.
2The results could mean a rare victory in a field filled with failed experiments to find an effective treatment for the disease.
3The companies said early results showed that the treatment reduced cognitive loss by 27 percent when compared to a placebo, an inactive substance.
4The 18-month-long study involved 1,800 subjects.
5All had been identified with early-stage Alzheimer's.
6The patients were measured for mental decline and their ability to do daily activities like putting on clothes and feeding themselves.
7Dr. Jeff Cummings is the director of the Chambers-Grundy Center for Transformative Neuroscience at the University of Nevada Las Vegas.
8The expert told Reuters, "If you can slow a disease by almost 30 percent, that's fantastic."
9Expert Ronald Petersen also praised the findings.
10"It's not a huge effect, but it's a positive effect," he said.
11Peterson directs the Mayo Clinic Alzheimer's Disease Research Center in Rochester, Minnesota.
12A statement from the Alzheimer's Association called the findings the most hopeful to date for possible treatments of the disease causes.
13Eisai said it would discuss the full results from the study in late November.
14It also plans to publish findings in a medical publication.
15And the company said it is seeking quick approval for the drug in the United States., Japan and Europe by early next year.
16The World Health Organization estimates that 50 million people around the world have dementia.
17Alzheimer's disease might be the cause of 60 to 70 percent of dementia cases.
18Alzheimer's slowly attacks areas of the brain needed for memory, reasoning, communication and basic, daily tasks.
19There is no known cure for the disease.
20And long-standing treatments on the market just manage symptoms.
21Last year, Biogen's aduhelm became the first new Alzheimer's drug introduced in 20 years.
22Given weak evidence of its effectiveness and the high prices, doctors and insurers have not given the treatment to patients.
23The beta-amyloid protein is involved in the development of Alzheimer's.
24Both lecanemab and aduhelm aim to remove the protein from the brain.
25But lecanemab tries to clear the protein before it could form a hard cover on the brain.
26Another drugmaker, Eli Lilly, said it is also developing a possible treatment, donanemab, that targets the protein.
27The race to slow the progression of Alzheimer's comes as the number of Americans living with the disease is expected to double to 13 million by 2050, the Alzheimer's Association said.
28Around the world, Alzheimer's Disease International said the number of disease cases could reach well over 100 million people by 2050 if no effective treatment is found.
29I'm Caty Weaver.
1Drugmakers Biogen and Eisai say their experimental drug lecanemab slowed the progress of Alzheimer's disease in a large human study the companies did. 2The results could mean a rare victory in a field filled with failed experiments to find an effective treatment for the disease. 3The companies said early results showed that the treatment reduced cognitive loss by 27 percent when compared to a placebo, an inactive substance. The 18-month-long study involved 1,800 subjects. All had been identified with early-stage Alzheimer's. The patients were measured for mental decline and their ability to do daily activities like putting on clothes and feeding themselves. 4Dr. Jeff Cummings is the director of the Chambers-Grundy Center for Transformative Neuroscience at the University of Nevada Las Vegas. The expert told Reuters, "If you can slow a disease by almost 30 percent, that's fantastic." 5Expert Ronald Petersen also praised the findings. "It's not a huge effect, but it's a positive effect," he said. Peterson directs the Mayo Clinic Alzheimer's Disease Research Center in Rochester, Minnesota. 6A statement from the Alzheimer's Association called the findings the most hopeful to date for possible treatments of the disease causes. 7Eisai said it would discuss the full results from the study in late November. It also plans to publish findings in a medical publication. And the company said it is seeking quick approval for the drug in the United States., Japan and Europe by early next year. 8What is Alzheimer's? 9The World Health Organization estimates that 50 million people around the world have dementia. Alzheimer's disease might be the cause of 60 to 70 percent of dementia cases. Alzheimer's slowly attacks areas of the brain needed for memory, reasoning, communication and basic, daily tasks. There is no known cure for the disease. And long-standing treatments on the market just manage symptoms. 10Last year, Biogen's aduhelm became the first new Alzheimer's drug introduced in 20 years. Given weak evidence of its effectiveness and the high prices, doctors and insurers have not given the treatment to patients. 11The beta-amyloid protein is involved in the development of Alzheimer's. Both lecanemab and aduhelm aim to remove the protein from the brain. But lecanemab tries to clear the protein before it could form a hard cover on the brain. 12Another drugmaker, Eli Lilly, said it is also developing a possible treatment, donanemab, that targets the protein. 13The race to slow the progression of Alzheimer's comes as the number of Americans living with the disease is expected to double to 13 million by 2050, the Alzheimer's Association said. 14Around the world, Alzheimer's Disease International said the number of disease cases could reach well over 100 million people by 2050 if no effective treatment is found. 15I'm Caty Weaver. 16Hai Do adapted this story for Learning English based on reporting from Reuters and The Associated Press. 17______________________________________________________________________ 18Words in This Story 19stage - n. a period of growth or development 20decline - v. to become worse 21dementia - n. a mental illness that causes someone unable to think or understand 22insurer - n. company that provides insurance